Melt-Cast Noninvasive Ocular Inserts for Posterior Segment Drug Delivery
نویسندگان
چکیده
منابع مشابه
Ocular Drug Delivery: Targeting the Posterior Segment
An inch or less. That is the short distance an ocular drug must travel to reach a target site at the back of the eye. Research has traveled a long way over the past 4 decades in efforts to make this inch-long journey more successful. Delivering ocular drugs to their target tissues often requires them to traverse the fatwater-fat structure of the corneal barrier, while ensuring minimum wastage t...
متن کاملOcular Drug Delivery: Targeting the Posterior Segment
One inch or less. That is the short distance an ocular drug must travel to reach a target site at the back of the eye. Research has come a long way over the past 4 decades in efforts to make this inch-long journey more successful. Delivering ocular drugs to their target tissues often requires them to traverse the fat-water-fat structure of the corneal barrier while ensuring minimum wastage thro...
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Over the recent decades, there has been seismic shift in the field of ocular drug delivery ranging from dosage form design to drug product commercialization. Advancements in the fields of nanotechnology, biomedical engineering and clinical science significantly improved the feasibility of ocular drug delivery. Despite these technological advances, there exists need to deliver drugs in therapeut...
متن کاملDrug delivery for posterior segment eye disease.
In recent years, significant advances have been made in optimizing the delivery of drugs to target tissues within the eye and in maintaining effective drug doses within those tissues. Most pharmacologic management of ocular disease, however, continues to use the topical application of solutions to the surface of the eye as drops. Factors that can limit the usefulness of topical drug application...
متن کاملThermoresponsive hydrogels as a new ocular drug delivery platform to the posterior segment of the eye.
PURPOSE To characterize thermoresponsive hydrogels (liquids at room temperature, gels at body temperature) as a novel drug delivery platform to the posterior segment. METHODS Thermoresponsive hydrogels were synthesized using poly(N-isopropylacrylamide) (PNIPAAm), cross-linked with poly(ethylene glycol) diacrylate (PEG-DA). Proteins were then encapsulated into the hydrogels, including bovine s...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2017
ISSN: 0022-3549
DOI: 10.1016/j.xphs.2017.07.017